Fever Induction

Pyrogens induce increases in hypothalamic beta-endorphins that trigger fever

Published in TB and Outbreaks Week, December 30th, 2003

Pyrogens induce increases in hypothalamic beta-endorphins that trigger fever; opioid receptor antagonist buprenorphine attenuates it in an animal model.

According to recent research from Taiwan, "at first, we investigated whether both 8-endorphin release level in the hypothalamus and body temperature can be altered after intracerebroventricular (i.c.v.) injection of either lipopolysaccharide (LPS), interleukin-1beta (IL-1beta), or prostaglandin E-2 (PGE₂ ) in rats.

"It was found that in the rat, i.c.v. administration of either LPS (0.5 microgr/10 microl), IL-1beta (10 ng/10 microl), or PGE₂ (200 ng/10 microl), in addition to...

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Source: TB and Outbreaks Week (2003-12-30)

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