Published in TB and Outbreaks Week, December 30th, 2003
According to recent research published in the journal Infection and Immunity, "the ability to infect host cells is critical for the survival and replication of intracellular pathogens in humans. We previously found that many genes involved in the ability of Legionella pneumophila to infect macrophages are not expressed efficiently under standard laboratory growth conditions.
"We have developed an approach using expression of L. pneumophila genes from an exogenous constitutive promoter on a low-copy-number...
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