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Antifungal Proteins

 Penicillium chrysogenum can inhibit some aspergilli with PAF protein

Published in TB and Outbreaks Week, January 6th, 2004

Penicillium chrysogenum produces an antifungal protein, PAF, that is internalized and works on some aspergilli.

"The Penicillium chrysogenum antifungal protein PAF inhibits the growth of various filamentous fungi," investigators in Austria report.

"In this study, PAF was found to localize to the cytoplasm of sensitive aspergilli by indirect immunofluorescence staining," wrote C. Oberparleiter and colleagues.

The researchers concluded: "The internalization process required active metabolism and ATP and was prevented by latrunculin B, suggesting an endocytotic mechanism."

Oberparleiter and...

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