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Bacteriology

Friendly bacteria shut down inflammation

Published in TB and Outbreaks Week, January 6th, 2004

How are we able to live happily with huge communities of various bacteria in our intestines, when many of them have the potential to cause inflammation'

In the January 2004 issue of Nature Immunology, scientists report that certain "friendly" gut bacteria help us to put out the "fire" started by harmful bacteria using a unique mechanism. This finding opens new avenues for designing drugs to treat chronic inflammation in the gut.

Our cells respond to harmful bacteria by using a key, known as NF-kappaB, to turn on the machinery (DNA transcription) that manufactures inflammation-causing proteins. However, Kelly and colleagues from the Rowett...

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