Septicemia Susceptibility

Mannose-binding lectin polymorphisms are linked to sepsis, related mortality

Published in TB and Outbreaks Week, January 6th, 2004

Mannose-binding lectin (MBL) polymorphisms providing for lower expression are linked to sepsis, related mortality.

According to a study from Denmark, "genetic factors may predispose critically ill patients to increased risk of developing sepsis. MBL is an important factor in innate immune defense.

"We investigated whether MBL gene polymorphisms causing low levels of MBL are associated with the development and progression of sepsis in adult patients in intensive care units. In 272 prospectively monitored patients with systemic inflammatory response syndrome, different MBL genotypes were compared, with respect to microbiology, sepsis development, and...

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Source: TB and Outbreaks Week (2004-01-06)

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