Published in TB and Outbreaks Week, January 13th, 2004
Two papers in the January 2004 issue of Nature Structural & Molecular Biology have reported the development of approaches to directly target an anthrax toxin to stop its lethal activity. These approaches complement the development of antibiotics that could prevent the spread of the bacteria.
Anthrax lethal factor, one of three toxins secreted by the deadly microorganism, causes cell death by inactivating key signaling molecules. Using parallel screening approaches, groups led by Lewis Cantley (Harvard Medical School) and Sina Bavari...
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