Tuberculosis Proteomics
Crystal structure of M. tuberculosis FbpC1 characterized
Published in TB and Outbreaks Week, January 13th, 2004
"The heterotrimeric antigen 85 complex (Ag85) is a major component of the cell wall of Mycobacterium tuberculosis and consists of three abundantly secreted proteins (FbpA, FbpB and FbpC2)," scientists in England explained. "These play key roles in the pathogenesis of tuberculosis and in maintaining cell-wall integrity."
"A homologue of the Ag85 subunits (approximately 40% identity) was recently annotated in the M. tuberculosis genome as FbpC1," noted R.A. Wilson and colleagues at the University of Birmingham. "Unlike the Ag85-complex components, FbpC1 lacks...
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