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HIV/AIDS Tuberculosis

Rifampicin does not affect enfuvirtide pharmacokinetics

Published in TB and Outbreaks Week, January 20th, 2004

Rifampicin treatment does not affect enfuvirtide pharmacokinetics in patients with HIV and tuberculosis infections.

Scientists in Thailand sought "to determine whether rifampicin influences the pharmacokinetics of enfuvirtide in HIV-1-infected patients."

"In a single-center, open-label, one-sequence crossover, clinical pharmacology study, 12 HIV-1-infected adults received enfuvirtide (90 mg, twice daily) on days one to three and days 11 to 13 (morning dose only on days three and 13) and rifampicin (600 mg, once daily) from days four to 13," explained M.A. Boyd and coauthors working with the HIV Netherlands Australia Thailand Research...

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