Viral Genomics & Genetics
South American dengue-1 viral genotypes determined
Published in TB and Outbreaks Week, January 20th, 2004
In a recent study, virologists in the United States "determined the complete coding sequences of six dengue-1 (DEN-1) viruses isolated from Paraguay and Argentina in 2000 from patients with dengue fever."
"Sequences of strains 259par00, 280par00, 295arg00, 297arg00 and 301arg00 can encode a polyprotein of 3,392 amino acids," according to G. Aviles and coauthors working at the University of Nevada.
"Strain 293arg00 circulated as a 'wild type + deletion mutant' quasispecies, with a subpopulation characterized by a 3-nucleotide deletion in the NS4A region," they...
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