Sexually Transmitted Diseases
Haemophilus ducreyi needs flp gene cluster to be virulent, form pustules
Published in TB and Outbreaks Week, January 27th, 2004
According to recent research published in the journal Infection and Immunity, "an intact Haemophilus ducreyi flp operon is essential for microcolony formation in vitro. TadA is the ninth of 15 genes in the operon, and has homology to NTPases of type IV secretion systems.
"Fifteen human volunteers were experimentally infected with both H. ducreyi 35000HP and the tadA mutant, 35000HP.400. Papules developed at similar rates at sites inoculated with the mutant and parent, while pustules formed at 36.4% of parent sites and at 0% of mutant sites...
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