Published in TB and Outbreaks Week, February 3rd, 2004
In a study from the United States, "CD40(-/-) mice succumbed to low-dose aerosol infection with M. tuberculosis due to deficient IL-12 production leading to impaired priming of IFN-gamma T-cell responses."
"In contrast, CD40L(-/-) mice were resistant to M. tuberculosis," noted V. Lazarevic and coauthors working at the University of Pittsburgh.
"This asymmetry in outcome of infection between the two knockout strains is likely due to the existence of an alternative...
Want to see the full article?
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of TB and Outbreaks Week
NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.