Tuberculosis Enzymology
Structure of mycobacterial EPSP synthase elucidated
Published in TB and Outbreaks Week, February 3rd, 2004
"The shikimate pathway is an attractive target for herbicides and antimicrobial agent development because it is essential in algae, higher plants, bacteria, and fungi, but absent from mammals," scientists in Brazil explained. "Homologues to enzymes in the shikimate pathway have been identified in the genome sequence of Mycobacterium tuberculosis. Among them, the EPSP synthase was proposed to be present by sequence homology."
"Accordingly, in order to pave the way for structural and functional efforts towards anti-mycobacterial agent development," J.H. Pereira and...
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