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Vectors and Zoonoses

 CYP6AA2 expression linked to An. minimus deltamethrin resistance

Published in TB and Outbreaks Week, February 17th, 2004

The An. minimus CYP6AA2 gene has been linked to deltamethrin resistance.

In a recent study from Thailand, "Two new genes in the cytochrome P450 (CYP6) family 6 with complete coding sequences were cloned and sequenced from deltamethrin-resistant Anopheles minimus, a major malaria vector in Thailand."

"CYP6P5 encodes a protein of 508 amino acids, while CYP6AA2 contains 505 residues," reported P. Rongnoparut and coauthors working at Mahidol University. "Each encoded protein contains a hydrophobic N-terminal region and a highly conserved heme-binding region typical of P450s."

"Alignments of deduced...

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