Tuberculosis Drug Resistance

IS6110 augments phoP transcription in MDR TB

Published in TB and Outbreaks Week, March 9th, 2004

IS6110 augments phoP transcription in an outbreak strain of drug-resistant tuberculosis.

"Drug resistance in Mycobacterium tuberculosis complex strains is solely due to chromosomal mutations that could affect bacterial virulence," according to biologists in Spain. "Molecular epidemiology studies have shown that resistant strains are less likely to be clustered than susceptible strains. However, a few multidrug-resistant (MDR) M. tuberculosis complex strains have been described as causing outbreaks, suggesting that they have restored virulence or increased transmission."

"One of the biggest MDR tuberculosis outbreaks...

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Source: TB and Outbreaks Week (2004-03-09)

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