Malaria Therapy
Alpha-lipoic acid protects rats from chloroquine-induced hepatotoxicity
Published in TB and Outbreaks Week, March 16th, 2004
In a study from India, "Oral administration of alpha-lipoic acid, a metavitamin, was investigated for its possible hepatoprotective effect in Wistar rats against chloroquine-induced toxicity."
"Rats were treated orally with alpha-lipoic acid (10, 30 and 100 mg/kg/day) for 7 days before a single oral administration of chloroquine (970 mg/kg/day) and alpha-lipoic acid treatment was continued for 3 more days," explained L. Pari and coauthors at Annamalai University.
"The increased level of serum enzymes (aspartate transaminase, alanine...
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