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Drug Development

Turkish propolis water extract has limited anti-TB efficacy

Published in TB and Outbreaks Week, March 23rd, 2004

An aqueous extract of Turkish propolis has limited antituberculosis efficacy in animals.

In a recent study from Turkey, a guinea pig model of M. tuberculosis H37Rv infection "was used to investigate the effect of water extract of propolis (WEP)."

"After subcutaneous inoculation of tubercle bacilli, each animal received oral WEP (n=9), isoniazid (n=5) or saline (n=6) as placebo and were sacrificed 30 days later," explained Z. Yildirim and coauthors at the University of Inonu.

"Formation of necrosis was less prominent in the group treated with WEP, but was not statistically significant (p>0.05)," test results revealed....

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