Tuberculosis Therapy
Location of M. tuberculosis KatG radical formation identified
Published in TB and Outbreaks Week, March 30th, 2004
M. tuberculosis KatG is "a heme-containing catalase-peroxidase responsible for activation, through its peroxidase cycle, of the front line antituberculosis antibiotic isoniazid (isonicotinic acid hydrazide)," scientists in the United States explained. "Formation of Compound I (oxyferryl heme-porphyrin pi-cation radical), the classical peroxidase intermediate generated when the resting enzyme turns over with alkyl peroxides, is rapidly followed by production of a protein-centered tyrosyl radical in this enzyme."
"In our efforts to identify the...
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