Tuberculosis Pathogenesis
M. tuberculosis inhibition of phagosome maturation reviewed
Published in TB and Outbreaks Week, April 13th, 2004
M. tuberculosis "persistence in human populations relies on its ability to inhibit phagosomal maturation," scientists in the United States explained. The bacterium "resides in a pathogen-friendly phagosome escaping lysosomal bactericidal mechanisms and efficient antigen presentation in the host phagocytic cell."
"M. tuberculosis phagosome maturation arrest includes the action of mycobacterial lipid products, which mimic mammalian phosphatidylinositols, targeting host cell membrane trafficking processes," noted J. Chua and colleagues at the...
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