Published in TB and Outbreaks Week, April 20th, 2004
In a recent study from England, "[f]our series of C-10 non-acetal dimers were prepared from key trioxane alcohol 10beta-(2-hydroxyethyl)deoxoartemisinin (9b)."
"All of the dimers prepared displayed potent low nanomolar antimalarial activity versus the K1 and HB3 strains of Plasmodium falciparum," reported J.P. Jeyadevan and coauthors at the University of Liverpool. "The most potent compound assayed was phosphate dimer 14a, which was greater than 50 times more potent than the parent drug artemisinin and about 15...
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