Published in TB and Outbreaks Week, April 20th, 2004
"Drug resistance and virulence of Mycobacterium tuberculosis are in part related to the pathogen's antioxidant defense systems," scientists in Germany explained. "KatG- strains are resistant to the first line tuberculostatic isoniazid but need to compensate their catalase deficiency by alternative peroxidase systems to stay virulent. So far, only NADH-driven and AhpD-mediated hydroperoxide reduction by AhpC has been implicated as such virulence-determining mechanism."
In a recent study, T. Jaeger and colleagues at the Technical...
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