Drug Development
Novel ribonuclease has antimicrobial and antiproliferative activities
Published in TB and Outbreaks Week, May 4th, 2004
In a recent study from China, a "12 kDa ribonuclease preferential for poly U and with much lower activity toward poly A, poly G and poly C was isolated from fresh fruiting bodies of the mushroom Pleurotus sajor-caju.
"A purification procedure involving ion exchange chromatography on CM-cellulose, affinity chromatography on Red-Sepharose and Heparin-Sepharose, and fast protein liquid chromatography-gel filtration on Superdex 75 was used," explained P.H.K. Ngai and coauthors at the Chinese University of Hong Kong.
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