Antimicrobial Drug Resistance
Plasmodium falciparum drug resistance in India determined
Published in TB and Outbreaks Week, May 4th, 2004
In a recent study, the P. falciparum "chloroquine resistance transporter (Pfcrt) K76T mutation and haplotype (amino acids 72-76) and the P. falciparum multidrug resistance 1 (Pfmdr1) mutation (N86Y) were analyzed as markers of chloroquine resistance in the DNAs of 73 blood samples from patients with P. falciparum malaria in India.
"Seventy of the 73 DNAs had the Pfcrt K76T mutation," reported P.G. Vathsala and coauthors at the Indian Institute of Science in Bangalore.
"Of these, 66...
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