Tuberculosis Enzymology
M. tuberculosis thioredoxin reductase characterized
Published in TB and Outbreaks Week, May 11th, 2004
M. tuberculosis H37Rv, "the causative agent of the dreaded disease tuberculosis, contains three thioredoxins and a single thioredoxin reductase," scientists in India explained. "Thioredoxin reductase is a member of the pyridine-nucleotide disulfide oxidoreductase family of flavoenzymes."
In a study conducted by M. Akif and coauthors at the Centre for DNA Fingerprinting and Diagnostics, the "thioredoxin reductase gene with a His tag at the C-terminus was expressed in Escherichia coli and purified.
"The dimeric (70 kDa) protein was...
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