Infectious Disease
Lipopolysaccharide O side chain determines Brucella virulence
Published in TB and Outbreaks Week, May 18th, 2004
"By comparing smooth wild-type Brucella strains to their rough mutants," scientists in Spain found that "the lipopolysaccharide (LPS) O side chain of pathogenic Brucella has a dramatic impact on macrophage activation.
"It favors the development of virulent Brucella by preventing the synthesis of immune mediators important for host defense," explained M.P. Jimenez de Bagues and colleagues working at the Diputacion General de Aragon.
This "O chain property is firmly linked to Brucella virulence," the researchers concluded.
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