Diagnostics

Fixed-trypomastigote EIA may be a suitable candidate for blood bank screening

Published in TB and Outbreaks Week, June 29th, 2004

A fixed-trypomastigote enzyme immunoassay may be a suitable candidate for blood bank screening.

According to recent research from Canada, "Three enzyme immunoassays (EIAs) for diagnosis of Chagas' disease were developed with fixed forms of Trypanosoma cruzi using a panel of 435 sera from the following groups: Venezuelan subjects positive by immunofluorescence (n=70), Venezuelan healthy controls (n = 85), healthy Canadians (n = 166), and subjects with other parasitic diseases (n=114)."

"All assays achieved 100% sensitivity and reasonable specificity for amastigotes (97.6%), epimastigotes (98.3%), and trypomastigotes (99.3%). The...

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Source: TB and Outbreaks Week (2004-06-29)

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