Infectious Disease

C. parvum enterocyte infection may affect expression of defensins

Published in TB and Outbreaks Week, June 29th, 2004

Cryptosporidium parvum enterocyte infection may affect expression of defensins.

"Invasion of enterocytes by pathogenic microbes evokes both innate and adaptive immune responses, and microbial pathogens have developed strategies to overcome the initial host immune defense. beta-Defensins are potentially important endogenous antibiotic-like effectors of innate immunity expressed by intestinal epithelia. In this study, the interplay between the enteric protozoan parasite Cryptosporidium parvum and host epithelial beta-defensin expression was investigated," investigators in England report.

"Using human and murine models of infection, we...

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Source: TB and Outbreaks Week (2004-06-29)

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