HIV/AIDS Transmission

HLA-DRB1 and -DQB1 variants associated with HIV-1 transmission events

Published in TB and Outbreaks Week, July 20th, 2004

HLA-DRB1 and -DQB1 variants are associated with HIV-1 transmission events.

"In 292 initially human immunodeficiency virus (HIV)-1-serodiscordant and cohabiting Zambian couples, HLA-DRB1 and -DQB1 variants were associated with HIV-1 transmission events during a 7-year follow-up period. Initially seronegative partners with either DRBI*0301-DQB1*0201 (relative hazard [RH], 1.60; P=0.009) or DRB1*1503-DQB1*0602 (RH, 1.67; P=0.03) showed accelerated seroconversion," wrote investigators at the University of Alabama.

"Carriage of DRB1*1301 in initially seropositive partners led to delayed transmission of HIV to their spouses (RH, 0.54; P=0.05). The combined...

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Source: TB and Outbreaks Week (2004-07-20)

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