Opportunistic Infection

Novel murine model of invasive pulmonary aspergillosis developed

Published in TB and Outbreaks Week, August 3rd, 2004

A novel murine aspergillosis model may facilitate research on this opportunistic infection.

Scientists in California devised a "model of invasive aspergillosis (IA) that recapitulates human disease."

"Mice were immunosuppressed with cyclophosphamide and cortisone acetate and then infected in an aerosol chamber," explained D.C. Sheppard and coauthors at the Harbor-UCLA Research and Education Institute in Torrance. "This procedure reproducibly delivered 1x10³ to 3x10³ conidia to the lungs."

"Lethal pulmonary IA developed over 2 weeks and was prevented by amphotericin B," the investigators concluded.

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Source: TB and Outbreaks Week (2004-08-03)

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