Allergy & Immunology

IL-1 receptor antagonist attenuates airway hyperresponsiveness to ozone

Published in TB and Outbreaks Week, August 17th, 2004

An interleukin-1 receptor antagonist prevents airway hyperresponsiveness following ozone exposure.

According to recent research from the United States, "The role of an interleukin (IL)-1 receptor antagonist (IL-1Ra) on the development of airway hyperresponsiveness (AHR) and airway inflammation following acute ozone (O₃ ) exposure in mice was investigated."

"Exposure of C57/BL6 mice to O₃ at a concentration of 2.0 ppm or filtered air for 3 hours resulted in increases in airway responsiveness to inhaled methacholine (MCh) 8 and 16 hours after the exposure, and an increase in neutrophils in the bronchoalveolar lavage (BAL) fluid,"...

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Source: TB and Outbreaks Week (2004-08-17)

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