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Streptococcus

Strep disrupts blood clotting to infect humans

Published in TB and Outbreaks Week, September 14th, 2004

University of Michigan researchers have captured a glimpse of the endless arms race between infectious agents and the human immune system in a bacterium that uses a mimic of a human blood-clotting enzyme to advance its infection.

Streptococcal bacteria use an enzyme called streptokinase to block the blood clotting response and allow themselves to move more freely around the human host's circulatory system. The molecule is so specific, it only works on humans, not on other animals.

"The theory is that, as bacteria cause a local infection and begin to grow, the clotting system produces clots in the blood vessels around the infection, closing the...

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