Anti-Infectives
Dinitroanilines disrupt protozoan microtubules by binding alpha-tubulin
Published in TB and Outbreaks Week, September 28th, 2004
"Protozoan parasites are remarkably sensitive to dinitroanilines such as oryzalin, which disrupt plant but not animal microtubules," scientists in the United States explained.
"To explore the basis of dinitroaniline action," N.S. Morrissette and colleagues at the University of California-Irvine "isolated 49 independent resistant Toxoplasma gondii lines after chemical mutagenesis."
"All 23 of the lines that we examined harbored single point mutations in alpha-tubulin," the collaborators said. "These point mutations were sufficient to confer resistance...
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