Pertussis

Bispecific monoclonal antibody detects causative agent of whooping cough

Published in TB and Outbreaks Week, October 5th, 2004

A bispecific monoclonal antibody is used to detect Bordetella pertussis, the causative agent of whooping cough.

According to a study from Canada, "A bispecific monoclonal antibody (bsMAb) that detects Bordetella pertussis, the causative agent of whooping cough, and horseradish peroxidase (HRPO) has been developed by use of the quadroma technology."

"A quadroma, P123, was produced by fusing two well-characterized hybridomas against the bacterium and the enzyme and was subcloned to obtain a stable bsMAb-secreting cell line.

"The quadroma was theoretically expected to produce up to 10 different molecular species of...

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Source: TB and Outbreaks Week (2004-10-05)

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