Breast Cancer
Cigarette smoke condensate induces transformation of normal breast cells
Published in TB and Outbreaks Week, October 12th, 2004
"In the present study, we showed that a single-dose treatment of normal breast epithelial cell line, MCF10A, for 72 hours with cigarette smoke condensate (CSC) resulted in a transformed phenotype," scientists in the United States report.
"The anchorage-dependent growth of these cells was decreased due to increased cell cycle arrest in S-G2 /M phase; however," said S. Narayan and coworkers, "the surviving cells developed resistance due to an increased Bcl-xL to Bax ratio.
"Levels of PCNA and gadd45 proteins - involved in DNA repair in response to...
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