Malaria Therapy
Novel azole-based compounds have anti-malarial activity
Published in TB and Outbreaks Week, October 12th, 2004
According to recent research from England, "Plasmodium falciparum, the causative agent of malaria, relies extensively on glycolysis coupled with homolactic fermentation during its blood-borne stages for energy production.
"Selective inhibitors of the parasite lactate dehydrogenase (LDH), central to NAD+ regeneration, therefore potentially provide a route to new antimalarial drugs directed against a novel molecular target."
"A series of heterocyclic, azole-based compounds are described that preferentially inhibit P. falciparum LDH at sub-micromolar...
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