Tuberculosis
Genetic susceptibility to tuberculosis in Africans is polygenic
Published in TB and Outbreaks Week, November 30th, 2004
"Twenty-seven polymorphisms from 12 genes have been investigated for association with tuberculosis (TB) in up to 514 cases and 9.1.3 controls from Karonga district, northern Malawi. Homozygosity for the complement receptor 1 (CR1) Q1022H polymorphism was associated with susceptibility to TB in this population (odds ratio [OR]=3.12, 95% confidence interval [CI]=1.13-8.60, P=0.028).
"This association was not observed among human immunodeficiency virus (HIV)-positive TB cases, suggesting either chance association or that HIV status may influence genetic associations with TB...
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