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Pneumococcal Vaccine

 Streptococcus pneumoniae protects against fatal pneumococcal challenge

Published in TB and Outbreaks Week, December 7th, 2004

The ClpP protease of Streptococcus pneumoniae modulates virulence expression and protects against fatal pneumococcal challenge.

According to recent research from South Korea and Australia, "Streptococcus pneumoniae usually colonizes the nasopharynx of humans asymptomatically but occasionally translocates from this niche to the lungs, the brain, and the blood, causing potentially fatal infections. Spread to other host tissues requires a significant morphological change and the expression of virulence factors, such as capsular polysaccharide, and virulence proteins, such as pneumolysin (Ply), PspA, and CbpA. Modulation of the expression of pneumococcal...

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