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Cholera

Association of cytoskeleton with cholera toxin-ganglioside complex

Published in TB and Outbreaks Week, December 21st, 2004

Researchers from the United States have shown that the trafficking of cholera toxin-ganglioside G(M1) complex into golgi and the induction of toxicity depends on the actin cytoskeleton.

"Intestinal epithelial lipid rafts contain ganglioside G(M1) that is the receptor for cholera toxin (CT). The ganglioside binds CT at the plasma membrane (PM) and carries the toxin through the trans-Golgi network (TGN) to the endoplasmic reticulum (ER). In the ER, a portion of the toxin unfolds and translocates to the cytosol to activate adenylyl cyclase," wrote K. Badizadegan and colleagues.

"Activation of the cyclase leads to an increase in intracellular cAMP, which...

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