Published in TB and Outbreaks Week, December 21st, 2004
"Intestinal epithelial lipid rafts contain ganglioside G(M1) that is the receptor for cholera toxin (CT). The ganglioside binds CT at the plasma membrane (PM) and carries the toxin through the trans-Golgi network (TGN) to the endoplasmic reticulum (ER). In the ER, a portion of the toxin unfolds and translocates to the cytosol to activate adenylyl cyclase," wrote K. Badizadegan and colleagues.
"Activation of the cyclase leads to an increase in intracellular cAMP, which...
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