Obesity Research
Caloric restriction mimetics include lipid-activated nuclear receptor agonists
Published in TB and Outbreaks Week, January 11th, 2005
"The obesity epidemic in industrialized countries is associated with increases in cardiovascular disease (CVD) and certain types of cancer. In animal models, caloric restriction (CR) suppresses these diseases as well as chemical-induced tissue damage.
"These beneficial effects of CR overlap with those altered by agonists of nuclear receptors (NR) under control of the fasting-responsive transcriptional co-activator, peroxisome proliferator-activated co-activator 1alpha (PGC-1alpha)," wrote investigators in the United States.
"In a screen for compounds...
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