Virology

Equine herpesvirus type 1 (EHV-1) glycoprotein K required for virulence

Published in TB and Outbreaks Week, January 11th, 2005

Researchers from Germany have described that equine herpesvirus type 1 (EHV-1) glycoprotein K (gK) is required for efficient cell-to-cell spread and virus egress.

"The function of the EHV-1 gK homologue was investigated. Deletion of 88% of the UL53-homologous open reading frame in EHV-1 strain RacH resulted in a severe growth defect of the gK-negative virus (HDeltagK) as reflected by a significant decrease in the production of infectious virus progeny on RK13 cells," wrote A. Neubauer and colleagues, University Munich.

"The HDeltagK virus induced only minute plaques, was unable to form syncytia, and its penetration efficiency into RK13 cells was...

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Source: TB and Outbreaks Week (2005-01-11)

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