Argemone oil is genotoxic

"Consumption of mustard oil adulterated with argemone oil leads to a clinical condition, commonly referred to as 'Epidemic Dropsy.'

"Since in vitro studies have shown that sanguinarine, an active benzophenanthridine alkaloid of argemone oil, intercalates DNA molecule, the in vivo clastogenic and DNA damaging potential of argemone oil was investigated in mice," researchers in India report.

Swiss albino mice were intraperitoneally administered 0.5, 1.0, 2.0 and 4.0 ml/kg body weight of argemone oil to analyze chromosome aberrations and micronucleus test, while 0.25, 0.5, 1.0 and 2.0 ml/kg body weight were...

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