Food-Borne Disease
Polymyxin B attenuates Salmonella-induced endotoxin shock
Published in TB and Outbreaks Week, February 8th, 2005
In a recent study from Japan, the protective effects of PLB, "having lipopolysaccharide (LPS)-binding activity, on infection-induced endotoxin shock in mice were investigated."
"Infection with 108 colony forming units of an attenuated Salmonella typhimurium aroA strain caused lethal endotoxin shock to ddY mice," H. Morita and coauthors at the Seikagaku Corporation found.
"Treatment with PLB 1 h post-infection (p.i.) resulted in significant reduction of mortality and bacterial numbers in livers," test results...
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