Drug Development
HIV/HTLV-1 protease inhibitors and antimalarial compounds developed
Published in TB and Outbreaks Week, February 22nd, 2005
According to a study from Japan, "Aspartic proteases have emerged as targets for substrate-based inhibitor design due to their vital roles in the life cycles of the organisms that cause AIDS, malaria, leukemia, and other infectious diseases.
"Based on the concept of mimicking the substrate transition-state, we designed and synthesized a novel class of aspartic protease inhibitors containing the hydroxymethylcarbonyl (HMC) isostere."
"An unnatural amino acid, allophenylnorstatine [Apns; (2S,3S)-3-amino-2-hydroxy-4-phenylbutyric acid], was incorporated at the...
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