Tuberculosis

Expression of IL-27 during TB is detrimental to the control of bacteria

Published in TB and Outbreaks Week, March 15th, 2005

Expression of IL-27 during tuberculosis (TB) is detrimental to the control of bacteria, reducing the ability of CD4 T cells to produce large amounts of IFN-gamma.

According to a study from the United States, "Resistance to tuberculosis (TB) is dependent on the induction of Ag-specific CD4 Th1 T cells capable of expressing IFN-gamma. Generation of these T cells is dependent upon IL-12p70, yet other cytokines have also been implicated in this process. One such cytokine, IL-27, augments differentiation of naive T cells toward an IFN-gamma-producing phenotype by up-regulating the transcription factor T-bet and promoting expression of the IL-12Rbeta2 chain allowing T cells...

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Source: TB and Outbreaks Week (2005-03-15)

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