Published in TB and Outbreaks Week, March 29th, 2005
Study 1: Surprisingly, plasmodial digestive vacuole plasmepsins are functionally redundant, which may limit their potential as malaria drug targets.
"The digestive vacuole plasmepsins PfPM1, PfPM2, PfPM4, and PfHAP (a histoaspartic proteinase) are four aspartic proteinases among 10 encoded in the Plasmodium falciparum malarial genome," scientists in the United States explained. "These have been hypothesized to initiate and contribute significantly to hemoglobin degradation, a catabolic function essential to the survival of this intraerythrocytic parasite."
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