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Amoebiasis

Key molecules in E. histolytica tissue invasion identified

Published in TB and Outbreaks Week, March 29th, 2005

Several molecules playing key roles in Entamoeba histolytica tissue invasion have been identified using a novel imaging system.

E. histolytica is "the human parasite responsible of amoebiasis, during which highly motile trophozoites invade the intestinal epithelium leading to amoebic colitis, and disseminate via the blood circulation causing liver abscesses," microbiologists in France explained. "The invasive process, central to the pathogenesis, is known to be driven by parasites motility."

"To investigate molecules responsible for in vivo motion," E. Coudrier and colleagues at the Curie Institute in Paris "performed a high resolution...

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