Drug Design

Scientists find missing enzyme for tuberculosis iron scavenging pathway

Published in TB and Outbreaks Week, April 19th, 2005

Scientists have discovered that a protein that was originally believed to be involved in tuberculosis antibiotic resistance is actually a "missing enzyme" from the biosynthetic pathway for an agent used by the bacteria to scavenge iron.

The research appeared in the April 8, 2005, issue of the Journal of Biological Chemistry.

Mycobacterium tuberculosis, the causative agent of tuberculosis, is responsible for more morbidity in humans than any other bacteria. The emergence of multidrug-resistant strains of M. tuberculosis has prompted the search for new drug targets and a better understanding of the mechanism of resistance in this...

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Source: TB and Outbreaks Week (2005-04-19)

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