Published in TB and Outbreaks Week, April 19th, 2005
According to a study from England, "The rapid technique of pyrosequencing was used to examine 123 samples (in the form of DNA extracts and inactivated sputum) of Mycobacterium spp.
"Of 99 Mycobacterium tuberculosis samples investigated for single-nucleotide polymorphisms (SNPs), 68% of isoniazid-resistant isolates analyzed had an AGC->ACC mutation in katG at codon 315, resulting in the Ser->Thr substitution associated previously with isoniazid resistance."
"Of the rifampicin-resistant isolates," wrote C. Arnold...
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