Mycobacterium Tuberculosis
MTB Ag 85B phagosomal processing modulated independently of viability/maturation
Published in TB and Outbreaks Week, April 26th, 2005
"Control of Mycobacterium tuberculosis infection requires CD4 T-cell responses and major histocompatibility complex class II (MHC-II) processing of M. tuberculosis antigens (Ags). We have previously demonstrated that macrophages process heat-killed (HK) M. tuberculosis more efficiently than live M. tuberculosis.
"These observations suggested that live M. tuberculosis may inhibit Ag processing by inhibiting phagosome maturation or that HK M. tuberculosis may be less resistant to Ag...
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