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Meningococcal Disease

Sequence variation in meningococci porB gene cause of New Zealand epidemic

Published in TB and Outbreaks Week, April 26th, 2005

A sequence variation in the meningococci porB gene was the cause of an epidemic in New Zealand.

According to published research from New Zealand, "Since mid-1991, New Zealand has experienced an epidemic of meningococcal disease. The epidemic has been caused by serogroup B meningococci expressing PorA type P1.7-2,4, belonging to the ST-41/ST-44 complex, lineage III."

"Most B:P1.7-2,4 meningococci express type 4 PorB (87.0%), although case isolates with porB other than type 4 have been identified throughout the duration of the epidemic. To assess the genetic relatedness of case isolates with an alternative porB gene, multilocus restriction typing...

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