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TB and Outbreaks Week

Susan Hasty, Publisher

Table of Contents . . . May 10th, 2005

Non-Subscriber - Summaries Only

Related Areas: Other Issues in TB and Outbreaks Week | Other Publications

Bacteriology -  Yersinia species survive and multiply in macrophage phagosomes

Bioterrorism - Multiplexed PCR assay simultaneously detects four biothreat agents

Diagnostics - PCR detects pathogenic leptospires earlier than in tissue culture

Diagnostics - Toxigenic culture sensitive for diagnosis of C. difficile-assoc. diarrhea

Acute Myeloid Leukemia - Arsenic trioxide represses activation of NF-kappa B/COX-2 in AML cells

Anthrax - Project could lead to anthrax drugs

Anti-Infectives - Ramoplanin is highly active against drug-resistant C. difficile in vitro

Anticancer Therapy - Jasmonates act directly and selectively on cancer cell mitochondria

Apoptosis - Bax and Bak genes required for apoptosis induction by sulforaphane

Apoptosis - Cyclooxygenase-2 inhibits ginseng metabolite-mediated apoptosis

Malaria Vaccines - Researchers publish new studies and findings in the area of malaria vaccines

Artificial Blood Substitute - Liposome-encapsulated actin-Hb used to develop artificial blood substitutes

Avian Influenza - Avian flu outbreak control integrated human & veterinary health response efforts

Brain Cancer - Mobile phone use not associated with risk of parietal/temporal lobe brain tumors

Breast Cancer - BRCA1/2 germline mutations evaluated in breast cancer moderate/low-risk persons

Bronchiolitis - Chest physiotherapy doesn't help infants with chest infection

Clostridium Difficile - slpA gene sequenced from C. difficile strains causing outbreaks in Japan

SARS - Researchers' work adds to SARS body of knowledge

Colon Cancer - Short-term risk for colonic polyps in I1307K APC mutation is low

Dengue Fever - Gene variant associated with protection from severe dengue in Thailand

Dengue Fever - Weather variables sometimes influence epidemics

Disseminated Tuberculosis - Disseminated TB presented as multiple hepatosplenic microabscesses/pancytopenia

Drug Development - Carbamic acid derivative shows promise for hepatic amoebiasis treatment

Drug Development - Developed pyrrole derivatives have antimycobacterial activity

Drug Development - Febrifugine analogs show promise as antimalarial agents

Drug Development - Oligosaccharides weak inhibitors of mycobacterial arabinosyltransferases

Drug Resistance - Co-artemether may reduce selective transmission of resistant parasites

Enteric Infections - Rifaximin active against enteric infections

Epidemiology - Multiple C. difficile strains in fecal samples limits epidemiology studies

Foodborne Illness - 2010 health goals for E. coli 0157 reached

Genetics & Genomics - Commensal Escherichia coli strain harbors many 'virulence-associated' genes

Genetics & Genomics - O-specific LPS gene cluster identified in CF-associated B. cenocepacia

HIV/AIDS Therapy - Mutations in HIV subtypes must be better understood to prevent resistance

Herpes Simplex Virus - HSV encephalitis during acyclovir therapy reported in premature infant

Influenza Vaccine - Inactivated influenza vaccine prevents influenza in diabetic mice

Listeria Diagnostics - Standardization needed for L. monocytogenes detection

Malaria - Antioxidants reduce endothelial cell apoptosis in malaria

Malaria - Researchers unmask malaria parasite's cloaking mechanism

Malaria - TOMOCOMD-CARDD approach identifies antimalarial compounds

Malaria Epidemic - Link between climate variability and malaria epidemics still unproven

Malaria Genomics and Genetics - Mutations linked to chloroquine resistance lower Plasmodium fitness

Malaria Transmission - Entomological features of malaria transmission in Manhica reported

Malaria Vaccines - New data illuminates research in malaria vaccines

Measles - Plant-based measles vaccine has potential

Mycobacterium Tuberculosis - MTB & M. smegmatis mutants increased beta-lactam antibiotic susceptibility

Mycobacterium Tuberculosis - MTB evades host antimicrobial defenses by inhibiting phagosome maturation

Mycobacterium Tuberculosis - Molecular techniques differentiate MTB strains by genetic polymorphisms

Mycobacterium Tuberculosis - Pathway critical for MTB virulence conserved & functional in M. smegmatis

Mycobacterium Tuberculosis - Peptidoglycan hydrolase Cw1M identified in Mycobacterium tuberculosis

Nosocomial Infections -  L. pneumophila persist in water supply regardless of disinfection procedures

Nosocomial Infections - Nosocomial outbreak-related respiratory pathogens reviewed

Peripheral Arterial Occlusive Disease - Anti-C. pneumoniae treatment inhibits PAOD progression

Proteomics - Rv3676 protein naturally defective in Mycobacterium bovis BCG strains

Psittacosis Outbreaks - Psittacosis outbreak may be linked to wild birds

SARS - Misconceptions about SARS lead to psychological trauma

SARS Coronavirus - SARSCoV mutation rates correlate with geographic epidemic characteristics

SARS Coronavirus - Safe & sensitive Spike protein-based IFA detects antibody responses to SARS-CoV

Staphylococcus - Research yields new approach for controlling drug-resistant infection

Staphylococcus Aureus -  S. aureus nasal carriage not assoc. with Vitamin D receptor gene mutation

Tobacco Use - Diet and tobacco exposure to acrylamide influence hemoglobin AA-adduct levels

Transfusion Medicine - Prestorage leucodepletion reduces transfusion reactions events

Travel Medicine - New survey shows few seek health advice prior to trip

Tuberculosis - Assays to determine vaccinated from M. bovis infected cattle improved

Tuberculosis - Isoniazid binds to NAT enzyme in mycobacterial cells

Tuberculosis Diagnosis - Culture more sensitive than PCR for extrapulmonary tuberculosis diagnosis

Tuberculosis Drug Development -  Quinchamalium majus constituents have potential antitubercular activity

Tuberculosis Vaccine - Prescreening program tested a wide range of tuberculosis vaccines

Tuberculosis Verrucosa Cutis - Diagnostic criteria for tuberculosis verrucosa cutis discussed

Typhoid Fever -  Salmonella electrophoresis patterns linked to travel analyzed

Urogenital Cancer - Immunogenetic basis for high urogenital cancer prevalence in sea lions

Vaccine Efficacy - Immunizations benefitting college students reviewed

West Nile Virus - NIAID begins clinical trial of West Nile virus vaccine

West Nile Virus - Studies describe new findings in west nile virus research

Yersinia - Invasin triggers Rac1-mediated signals enabling Yersinia internalization

Yersinia - LAT/SLP-76 molecules targeted by Yersinia to inhibit T cell activation

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